I had a similar problem coming out of a cave from Pleasant Valley into Winding River. The screen was black until I made another zone transition, and I discovered that all of my gear had been reset to starting gear. Reloading didn't fix it, quitting and restarting didn't fix it. My run is toast now.
There's a whole thread on this on the Steam forums with multiple similar reports: https://steamcommunity.com/app/305620/discussions/4/3717188878659883390/
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